https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Increased peripheral blood pro-inflammatory/cytotoxic lymphocytes in children with bronchiectasis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23403 Wed 11 Apr 2018 15:33:10 AEST ]]> The practicality of including the systemic inflammatory response syndrome in the definition of polytrauma: experience of a level one trauma centre https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18945 38 °C or <36 °C; Pulse >90 bpm; RR > 20/min or a PaCO₂ < 32 mmHg; WCC > 12.0 × 10⁹ L⁻¹, or <4.0 × 10⁹ L⁻¹, or the presence of >10 immature bands) collected from presentation, at 24 h intervals until 72 h post injury. Inclusion criteria were all patients generating a trauma team activation response age >16. Results: 336 patients met inclusion criteria. In 46% (155/336) serial SIRS scores could not be calculated due to missing data. Lowest rates of missing data observed on admission [3% (11/336)]. Stratified by ISS > 15 (132/336), in 7% (9/132) serial SIRS scores could not be calculated due to missing data. In 123 patients ISS > 15 with complete data, 81% (100/123) developed SIRS. For Abbreviated Injury Scale (AIS) > 2 in at least 2 body regions (64/336) in 5% (3/64) serial SIRS scores could not be calculated, with 92% (56/61) of patients with complete data developing SIRS. For Direct ICU admissions [25% (85/336)] 5% (4/85) of patients could not have serial SIRS calculated [mean ISS 15(±11)] and 90% (73/81) developed SIRS at least once over 72 h. Conclusion: Based on the experience of our level-1 trauma centre, the practicability of including SIRS into the definition of polytrauma as a surrogate for physiological derangement appears questionable even in prospective fashion.]]> Sat 24 Mar 2018 07:58:52 AEDT ]]> Incidence of multiple organ failure in adult polytrauma patients: a systematic review and meta-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52615 3, 12.7% (95% CI, 9.3-16.1%) in Denver score >3 with blunt injuries only, 28.6% (95% CI, 12-45.1%) in Denver score >8, 25.6% (95% CI, 10.4-40.7%) in Goris score >4, 29.9% (95% CI, 14.9-45%) in Marshall score >5, 20.3% (95% CI, 9.4-31.2%) in Marshall score >5 with blunt injuries only, 38.6% (95% CI, 33-44.3%) in SOFA score >3, 55.1% (95% CI, 49.7-60.5%) in SOFA score >3 with blunt injuries only, and 34.8% (95% CI, 28.7-40.8%) in SOFA score >5. Conclusion: The incidence of postinjury MOF varies largely because of lack of a consensus definition and study population. Until an international consensus is reached, further research will be hindered. Level of Evidence: Systematic Review and Meta-analysis; Level III.]]> Fri 10 Nov 2023 07:10:04 AEDT ]]>